Chamaeleon

Chamaeleon is an early-stage VC firm headquartered in Silicon Valley, investing globally in transformative startups. Their proprietary AI-driven engine, Mantis, is at the core of their strategy, enabling them to analyze massive data sets for high-quality deal sourcing, risk assessment, and portfolio management. This data-first approach gives them a competitive edge, spotting emerging trends faster than others. Their focus is on B2B startups, particularly in SaaS, cybersecurity, and cloud infrastructure, making significant bets in companies like Mysten Labs, Draft Kings, Robinhood, and Rubrik. Chamaeleon typically invests in Seed and Series A rounds and is not shy about leading investments. They maintain strong networks across the U.S. and Europe, especially with key players in cloud and enterprise tech. Co-founded by Alexandre Santos, the firm blends decades of experience in tech and corporate venture building, supporting portfolio companies with both capital and operational insights. The firm prefers working with founders who share their commitment to large-scale impact and often builds relationships through referrals within their extensive network. While they handle investments efficiently through their tech, human judgment remains integral in critical decisions. Chamaeleon’s distinct combination of data science and traditional VC expertise has led to top-tier returns, placing them in the top 2-5% of investors globally.