USA VC Funds

.406 Ventures, based in Boston, is an early-stage venture capital firm with over $1.4 billion under management. Founded in 2005, the firm focuses on investments in healthcare, data and AI, and cybersecurity. .406 Ventures partners with visionary entrepreneurs to build pioneering companies, offering substantial operational support and leveraging extensive industry networks. The firm's investment strategy includes participating in the first institutional capital rounds, typically investing between $2 million and $5 million initially, with significant reserves for follow-on investments. Notable portfolio companies include AbleTo, Carbon Black, CloudHealth Technologies, and Iora Health, all of which have been acquired by major corporations. .406 Ventures emphasizes a hands-on approach, ensuring each portfolio company benefits from the collective experience of the entire investment team. This approach includes helping companies navigate challenges, optimize business strategies, and scale successfully. The firm aims to foster long-term partnerships, providing not just capital but also strategic guidance and operational expertise.

01 Advisors is a venture capital firm founded in 2018 by former Twitter executives Dick Costolo and Adam Bain. Based in San Francisco, California, 01 Advisors focuses on early to growth-stage investments, particularly in the software, fintech, and tech-enabled services sectors. The firm aims to leverage its extensive operational experience to support startups transitioning from product development to building scalable businesses. The investment strategy of 01 Advisors includes backing visionary founders and providing strategic guidance to help them scale their companies. Notable investments include companies like Tipalti, Density, and Electric, which span industries such as financial software, electronic equipment, and IT consulting. The firm has raised multiple funds, with their first fund closing at $134 million and their third fund managing $395 million. They continue to be active investors, having made 55 investments to date, and are known for their hands-on approach in nurturing portfolio companies from the early stages through to potential exits.

10X Capital is a versatile alternative asset management firm headquartered in New York City, specializing in providing institutional investors access to high-growth opportunities across various asset classes. Founded by Hans Thomas and co-headed by David Weisburd, the firm aligns Wall Street with Silicon Valley, focusing on venture capital, private credit, private equity, and real estate investments. 10X Capital’s notable strategies include venture capital investments in high-growth technology companies through private equity and public markets. They also manage SPACs, IPOs, and securitization, leveraging a deep network and robust analytical capabilities to identify and nurture promising startups. The firm has successfully facilitated the growth of several technology-driven businesses, effectively bridging the gap between institutional capital and innovative ventures​. Key team members include Russell Read, Chief Investment Officer, who brings extensive experience from CalPERS and the Alaska Permanent Fund, and Guhan Kandasamy, Chief Data Officer, known for his expertise in credit risk and data management. The team’s diverse background enables 10X Capital to provide comprehensive support and strategic insights to their portfolio companies​​. The firm’s mission is to democratize access to capital markets, ensuring that high-potential ventures receive the necessary funding and support to scale efficiently. This commitment is evident in their broad range of services and their strategic focus on sectors like technology, real estate, and specialty finance

11.2 Capital is an early-stage venture capital firm based in San Francisco, focusing on breakthrough technologies in artificial intelligence, augmented reality/virtual reality (AR/VR), robotics, space, and data-driven health. They have built a diverse portfolio that includes companies such as Bay Labs, Deep Genomics, and Hinge Health. Their investment strategy centers on early-stage technology startups with the potential for significant impact. 11.2 Capital has made 51 investments, with notable exits including Cruise Automation and Kindred AI. They emphasize supporting companies that leverage data at molecular and behavioral levels to innovate in healthcare, such as Apixio and Hindsait, which use data to enhance patient care and reduce costs. The firm is led by a team with deep expertise in technology and investment. Shelley Zhuang, a notable figure in the venture capital world, brings extensive knowledge in cybersecurity and AI. 11.2 Capital's approach involves not only providing capital but also strategic support to help startups scale effectively. Overall, 11.2 Capital is dedicated to fostering innovation in tech-driven sectors, providing both financial backing and strategic partnerships to enable startups to reach their full potential​.

13 Ventures is a U.S.-based venture capital fund specializing in consumer-facing companies that are already generating revenue and are on a strong growth trajectory. The fund is particularly interested in businesses that demonstrate a clear path to profitability, aiming to back scalable models that can quickly capitalize on market opportunities. While their check sizes and deal specifics are not publicized, they focus on later stages, supporting companies in growing their market presence and operational capacity. Startups are encouraged to have a strong product-market fit and be ready for strategic scaling before approaching the fund. The fund emphasizes the importance of introductions, signaling that they prefer startups to come through a trusted network or via direct recommendations. They value concise and well-prepared pitches that highlight key business metrics such as revenue growth and market positioning. The goal is to ensure each company aligns with 13 Ventures' investment thesis, which centers around robust consumer-driven companies poised for significant expansion. 13 Ventures offers more than just capital; they provide hands-on support to help their portfolio companies overcome operational and growth challenges. Their experience and extensive network provide startups with access to critical resources, including mentorship and partnerships that can accelerate growth. Their ideal investments are in companies that have already proven their ability to generate revenue and are ready to scale to the next level, with a firm foundation and potential for profitability. This focus on high-growth consumer markets sets 13 Ventures apart as a key player in helping companies scale effectively.

1517 Fund, co-founded in 2015 by Michael Gibson and Danielle Strachman, is a venture capital firm with a distinctive focus on backing young founders, dropouts, and renegade scientists. The firm is inspired by the spirit of Martin Luther's 1517 Reformation, challenging the conventional education system and supporting innovators working outside traditional academic tracks. 1517 Fund invests in early-stage startups, including those at the R&D/idea phase up to the Seed stage. They are particularly interested in software, hardware with a data play, deep tech/science fiction tech, and biotech. Their initial investments range from $50,000 to $1,000,000, with an average check size of around $400,000 for pre-seed investments. Notable companies in 1517 Fund's portfolio include Luminar, Lambda, Deepgram, and Figma. They have a community-oriented approach, providing grants, investments, and support to a network of hackers, makers, and scientists globally. This community includes events, workshops, and office hours aimed at fostering innovation and advancing the edges of knowledge and science. The fund's co-founders, Michael Gibson and Danielle Strachman, previously worked with Peter Thiel on the Thiel Fellowship, which provided $100k grants to young entrepreneurs, leading to successful ventures like Ethereum and OYO Rooms. This background underscores their commitment to nurturing unconventional talent and groundbreaking ideas.

1776 Ventures, based in Washington, D.C., is a seed-stage venture capital firm with a focus on transformative startups addressing critical societal needs. Notable investments include Twiga Foods, a Nairobi-based agriculture and e-commerce platform; MPOWER Financing, providing financial services for higher education; and HopSkipDrive, a transportation solution for children. The fund primarily invests in sectors like healthcare, education, energy, smart cities, and fintech. Geographically, 1776 Ventures has a diverse portfolio with significant activity in the United States, particularly in California, Washington D.C., and New York, as well as international investments in Kenya and Brazil. Their strategy emphasizes early-stage investments, mostly seed and occasionally Series A rounds. They prefer to follow rather than lead, with an average check size of $3 million and typically around ten rounds per year. The firm was co-founded by Donna Harris and Evan Burfield, who bring extensive expertise and networks to support portfolio companies. They actively seek startups with strong potential for social impact and scalability. To approach 1776 Ventures, it is beneficial to have a clear demonstration of market need and a scalable business model. For startups looking to engage with 1776 Ventures, highlighting innovation in complex and high-impact sectors is crucial. The firm values proactive outreach from founders who can articulate a clear vision and demonstrate a tangible plan for growth and impact​.

1855 Capital is a seed and early-stage venture capital fund based in State College, Pennsylvania, with a focus on investing in startups connected to Penn State University. The fund, which has approximately $10 million under management, is dedicated to supporting companies emerging from Penn State's robust research and educational environment. This includes faculty, staff, students, and the extensive alumni network of over 700,000 members. The firm primarily targets sectors like information technology, advanced materials, fintech, edtech, and healthcare/medical devices. Investments typically range from $100,000 to $500,000, aiming to fill a critical early-stage funding gap for Penn State-affiliated startups, particularly those in underserved regions of Pennsylvania. The fund leverages its deep ties to the university and the broader business community to provide not just capital but also mentorship and strategic guidance, helping startups achieve significant milestones and scale effectively. Led by Managing Director Matt Rhodes, who has extensive experience in both startup and large-scale business management, 1855 Capital is committed to driving innovation within the Penn State ecosystem.

186 Ventures is a Boston-based venture capital firm, established in 2021, managing a $37M seed fund. Co-founded by Giuseppe Stuto and Julian Fialkow, the firm focuses on pre-seed and seed-stage investments, primarily in software sectors. They have a strong presence in fintech, AI, healthtech, blockchain, and SaaS. While their primary focus is on the Northeastern U.S., they also target high-growth startups across other major hubs like New York and San Francisco. 186 Ventures takes a generalist approach, investing in a wide range of tech-enabled companies but prioritizes capital-efficient startups that can demonstrate sustainable business models. With over 30 companies in their portfolio, including notable names like Centaur Labs, SuperWorld, and Monitaur, the firm aims to build out its portfolio further with 8-10 new investments in 2024. They are particularly founder-focused, offering strategic and operational support while leveraging their extensive network of operators and industry leaders to drive growth. Their average check size varies, but they typically lead early-stage rounds, with a keen eye on startups with strong capital efficiency and rapid growth potential. The team at 186 Ventures is highly accessible and hands-on, valuing founder alignment and supporting businesses through both market highs and lows​.

1863 Ventures is a Washington, D.C.-based nonprofit business development accelerator and venture capital fund dedicated to supporting "New Majority" founders—primarily Black, Latino, and other historically underestimated entrepreneurs. Founded by Melissa Bradley in 2016, 1863 Ventures is committed to creating $100 billion in new wealth for these entrepreneurs by helping them scale from high potential to high growth​. The organization offers a comprehensive suite of programs, including tailored curricula, access to capital, mentorship, and corporate partnerships, all designed to address the unique challenges faced by New Majority entrepreneurs. 1863 Ventures has supported over 3,200 entrepreneurs across the U.S., helping them generate significant revenue and raise millions in equity and debt financing​. Through its venture fund, 1863 Ventures has invested in a diverse portfolio of startups across various industries, such as software development, food products, and e-commerce. Notable investments include companies like Bonnti, Flexie, and Trade Street Jam​. 1863 Ventures' impact is deeply rooted in its commitment to economic empowerment and racial equity, making it a leading force in transforming the entrepreneurial landscape for underrepresented communities.

1955 Capital is a venture capital firm based in Los Altos, California, founded by Andrew Chung in 2015. The firm focuses on investing in advanced technologies from the Americas and Europe that can address significant challenges in developing countries, particularly in areas like energy, environment, food safety, health, education, and sustainable manufacturing. 1955 Capital’s investment strategy is driven by a mission to leverage breakthrough technologies to tackle some of the world’s most pressing issues. The firm aims to foster global partnerships, accelerate technology commercialization, and create substantial market opportunities. Their approach is deeply informed by the founder’s extensive experience in sustainability and health technologies, including involvement with several unicorns in these sectors during his time at Khosla Ventures. The firm has built a diverse portfolio, investing in companies that are pioneering innovative solutions across various industries. For instance, they have supported ventures in electric aviation, alternative proteins, energy storage, and surgical robotics. By focusing on these high-impact sectors, 1955 Capital seeks to create both financial returns and positive global change.

1984 Ventures, founded in 2018 and based in San Francisco, is a venture capital firm focusing on seed and early-stage investments in software businesses. The firm targets sectors such as fintech, healthcare, SaaS, e-commerce, and consumer technology. Their portfolio includes notable companies like Properly, Brace, and Heroes Jobs​. The firm has made 120 investments, with 9 successful exits to date, including Convex, which was acquired in 2024. 1984 Ventures has recently invested in companies like Fay, Collaborative Robotics, and Alaffia Health in 2024​. 1984 Ventures is led by founder and managing partner Ramy Adeeb, and they leverage their entrepreneurial experience to help portfolio companies grow. They emphasize supporting startups that apply technology to solve real-world problems​.

1confirmation is a venture capital firm founded by Nick Tomaino, focusing primarily on early-stage investments in the blockchain and cryptocurrency sectors. Based in San Francisco, the firm aims to support open networks that empower the masses by investing in companies that are building innovative blockchain-based solutions. 1confirmation's portfolio includes notable investments in companies like OpenSea, dYdX, and Nexus Mutual, highlighting their strong focus on the cryptocurrency space. Their investment strategy emphasizes early-stage opportunities, providing not just capital but also strategic guidance and industry connections to help startups grow. The firm is known for its deep commitment to the crypto ecosystem, often being one of the first institutional investors in pioneering blockchain projects. This approach allows them to take significant risks with the potential for high returns, following a philosophy that values transformational technologies over immediate profitability​​. The team at 1confirmation includes experienced professionals with a strong background in both venture capital and the cryptocurrency industry, allowing them to leverage their expertise and networks to support the growth of their portfolio companies effectively​.

1kx is a venture capital firm founded in 2018, specializing in early-stage investments with a focus on blockchain technology and decentralized ecosystems. The firm is headquartered in Road Town, British Virgin Islands, with additional offices in Berlin and Amsterdam. 1kx has made notable investments in several high-profile projects within the blockchain and DeFi sectors. Some of their key investments include Qredo, a blockchain network for DeFi applications; Matter Labs, which focuses on blockchain privacy and verifiable computation; and Rarible, an online marketplace for blockchain-based digital art. Other significant investments include Connext, which offers Ethereum-based P2P micro-payment infrastructure, and Gitcoin, a platform for funding open-source software development. The firm's investment strategy emphasizes supporting projects that build critical infrastructure for decentralized ecosystems. They have made 162 investments to date, with a strong presence in the United States, followed by Germany and France. The leadership team at 1kx includes founding partners Christopher Heymann and Lasse Clausen, along with Diana Biggs, who supports portfolio growth with an institutional lens.

1Up Ventures is a venture capital fund dedicated to supporting independent game developers. Founded by Ed Fries, a former Microsoft executive who played a pivotal role in the development of the Xbox, the fund is based in Kirkland, Washington. 1Up Ventures emphasizes building a diverse and inclusive community of talented, experienced, and creative indie game developers. The fund focuses exclusively on investing in game and content-focused studios, not platforms or tech-focused studios. 1Up Ventures typically does not act as a lead investor but supports founders through a community-driven approach. They invest a standard amount and percentage in their portfolio companies, emphasizing collaborative success. Key team members include Kelly Wallick, a partner and community builder who is also the founder of Indie MEGABOOTH, and Chris Wheaton, the fund administrator with extensive industry experience as a CFO, COO, and General Manager. The fund's portfolio features a variety of innovative game development studios, reflecting their commitment to a broad and inclusive portfolio approach.

212 Angels, also known as 212 Ventures, is a leading venture capital firm focused on backing B2B technology startups that are ready to scale globally. Based in Istanbul, with additional offices in Doha, Dubai, and San Francisco, 212 has a strong regional presence but operates with a global perspective. The firm has invested in numerous innovative companies, supporting them through various stages of growth. Notable investments include Metrobi, a last-mile logistics platform, and Fazla, which provides tech-enabled solutions for waste management and has significantly reduced food waste and carbon emissions. Other key portfolio companies are Trio Mobil, which offers industrial IoT solutions, and AppSamurai, a mobile marketing technology firm. 212 Angels typically invests in seed to Series A rounds, with initial investments ranging from $500K to $5M. They focus on sectors like fintech, logistics, AI, and SaaS, providing both capital and strategic support to help startups expand internationally. Their approach emphasizes a hands-on partnership with founders, leveraging their extensive network and expertise to drive growth. The leadership team, including founder and managing director Ali Karabey, brings a wealth of experience in venture capital and entrepreneurship. They pride themselves on their ability to identify and nurture high-potential startups, helping them navigate the challenges of scaling and achieving global success. For startups looking to attract investment from 212 Angels, it’s crucial to demonstrate a strong product-market fit and potential for international growth. The firm values innovation, scalability, and the ability to solve significant problems in their respective industries.

2048 Ventures is a venture capital firm founded in 2018 and headquartered in New York, NY. The firm focuses on early-stage investments, particularly in technology-driven startups. They have a strong portfolio with over 120 investments across diverse sectors, including biotechnology, artificial intelligence, health tech, and commercial products. Some notable companies backed by 2048 Ventures include Adaptis Technologies, an AI-powered platform for optimizing the carbon footprint of buildings, and Fathom Optics, which delivers 3D experiences using standard printing technologies. Their investment strategy is to support visionary founders at the earliest stages, often leading pre-seed and seed rounds. 2048 Ventures has shown significant activity, with their portfolio companies collectively raising $591 million and reaching a valuation of $2.6 billion by the end of 2023. They have invested in innovative companies like TwoStep Therapeutics, which specializes in modular peptide technology for targeting solid tumors, and Century Health, which leverages AI to accelerate drug development​.

2150 is a London, Copenhagen, and Berlin-based venture capital firm focused on transforming urban environments through sustainable technology. With a €268 million fund, 2150 invests in companies that address major challenges across the "Urban Stack"—everything from the design and construction of cities to how they are powered and maintained. Their mission is to support groundbreaking startups that can reimagine urban living, while significantly reducing carbon emissions and improving sustainability. 2150 primarily invests in Series A and B stage companies, with check sizes ranging from $1 million to $7 million. Their focus spans climate tech, green solutions, and innovative materials, all aimed at creating smarter, more efficient cities. The firm’s portfolio includes companies like CarbonCure, which injects recycled CO₂ into concrete to reduce its carbon footprint, Normative, a platform that helps businesses track and manage their carbon emissions, and Ampd Energy, which electrifies construction sites to minimize pollution. Beyond financial backing, 2150 takes a hands-on approach, working closely with founders to scale their businesses and maximize impact. The firm’s ultimate goal is to build a portfolio capable of mitigating gigatonnes of CO₂ emissions, comparable to the entire annual output of countries like Germany and France. With strong backing from investors like Novo Holdings and the BMW Foundation, 2150 is positioned as a key player in the future of urban development, driving both commercial success and global sustainability.

25madison, established in 2018, is a venture capital firm and startup studio based in New York City. The firm specializes in co-incubating ideas, investing in early-stage startups, and propelling companies into their next growth phase. The venture studio and fund focus on pre-seed to seed-stage investments, particularly in healthcare, fintech, and B2B SaaS sectors. 25madison operates a comprehensive platform that includes a flagship venture studio, a dedicated healthtech studio, and a supply chain studio. This platform supports startups by providing strategic guidance, operational expertise, and capital. The firm prides itself on its bespoke model for early-stage businesses, offering hands-on involvement in business strategy, product development, brand creation, and go-to-market execution. The team at 25madison includes experienced entrepreneurs and investors who bring deep industry knowledge and a track record of building and scaling successful companies. Key team members include Matthew Fremont-Smith, Steven Price, and Michael Lynton. Notable investments from 25madison include companies like Truehold, Pattern, and Handspring Health, which showcase their commitment to transformative products and innovative business models. The firm also collaborates closely with Apollo Global Management, leveraging their network and resources to enhance their startups' growth prospects.

27V (Twenty Seven Ventures) is a venture capital firm that focuses on early-stage investments in EdTech (education technology) and Future of Work startups. The firm was founded by Atin Batra and is headquartered in the Cayman Islands. Since its inception in late 2019, 27V has invested in 28 companies across regions including North America, Europe, and Asia Pacific (excluding India and China). 27V typically invests at the pre-seed and seed stages, with initial checks ranging from $50,000 to $250,000, and reserves funds for follow-on investments. The firm is more than just a fund; it promotes a "Founder Fellowship" that emphasizes community and connections among founders and their teams, facilitating shared learning and support. Notable investments in their portfolio include companies like Fluent, which aims to revolutionize language learning, and Preteckt, which uses machine learning to predict maintenance issues in vehicles. 27V's unique approach includes a scout network that helps identify promising startups from underrepresented communities, fostering diversity and inclusion in the venture capital ecosystem.

2xN is a London-based, quantum-focused venture capital fund co-founded by Lars Fjeldsoe-Nielsen and Niels Nielsen. The firm specializes in early-stage investments, primarily targeting startups in quantum computing and other sectors with transformative potential like mobility, edtech, and marketplaces. Notable investments include quantum heavyweights Quantinuum and Kvantify, as well as StudySmarter, demonstrating its focus on impactful technologies. With a $120 million fund, 2xN typically invests $3 to $5 million in pre-seed to Series A rounds, actively backing companies across Europe and the U.S. The fund's strategy is highly collaborative, often co-investing with prominent VCs like Sequoia and A16Z, favoring founders with a vision for societal impact. Rather than dominating deals, 2xN aims to create network effects and long-term partnerships, making them a hands-on, founder-first investor. The team’s dual expertise—Nielsen’s pioneering work in quantum computing and Fjeldsoe-Nielsen’s background in Silicon Valley—enables them to offer deep, technical guidance while scaling businesses rapidly. Startups are encouraged to approach the fund with disruptive ideas in core sectors like quantum, as 2xN builds its deal flow through a strong network of repeat entrepreneurs and global investors.

305 Ventures, based in Miami, is a venture capital firm that focuses on early-stage investments, primarily targeting pre-seed and seed-stage companies across diverse sectors. Founded by Zaid Rahman, Joey Levy, and Michael Melikian in 2021, the firm is run by active founders who invest in other entrepreneurs, helping them navigate growth challenges with hands-on support and strategic guidance. 305 Ventures has a broad investment scope, ranging from fintech, sports media, entertainment, and web3 to consumer products. Their portfolio includes notable companies such as Underdog Fantasy, Rain (a fintech platform), Voldex (a Roblox and Minecraft game developer), Betr (a micro-betting app), and Los Dos Tequila. The firm has also invested in companies that leverage web3 and NFTs, such as Passes and Dropverse. The firm is committed to accelerating Miami's emergence as a tech hub, attracting founders from cities like LA, New York, and Silicon Valley, and helping them integrate into the local ecosystem. 305 Ventures often partners with Florida Funders and other co-investors to support startups in scaling their operations while building a robust community in Miami. With plans to invest in 40 companies, the firm is set on nurturing the next generation of billion-dollar businesses.

360 Venture Collective is a woman-founded and led venture capital firm based in Miami, focusing on pre-seed and seed-stage investments. The firm is dedicated to supporting historically underestimated founders, particularly women and LGBTQ+ entrepreneurs, across sectors like fintech, healthtech, proptech, and the future of work. Their inclusive investment strategy aims to foster innovation while driving social impact. Founded in 2021, the firm typically invests between $50,000 and $500,000 per venture. They also provide operational and strategic support through their Arc Accelerator, helping startups scale effectively. Key team members include Managing Partner Kelly O'Connell and General Partners Ann Metzger and Shelley Iocona, all of whom bring extensive experience in entrepreneurship and corporate leadership. Recent investments include startups like HUSSLUP and Upside Health, demonstrating 360 Venture Collective's focus on high-potential, tech-enabled businesses.

37 Angels is an angel investment network founded in 2012, headquartered in New York, NY. The firm is dedicated to closing the gender gap in startup investing by training more women to become angel investors and by investing in high-potential, diverse startups. Each year, 37 Angels evaluates around 2,500 startups and invests in approximately 10, focusing on both male and female-led companies. Their portfolio includes a variety of innovative startups across different sectors. Notable investments include ChalkTalk, an e-learning platform, Partake Foods, a food products company, and EarlyBird, a financial software firm. They also have significant investments in companies like Pulp Pantry, which focuses on sustainable food products, and Sensate, which provides health and wellness solutions. 37 Angels has had multiple successful exits, such as Owlet Baby Care, which went public, and Kinsa Health, which was acquired by a larger firm. Their investment strategy involves supporting startups from early stages through to growth, offering both capital and strategic guidance to help them scale.

3B Ventures is an impact-driven venture capital firm founded in 2017 with headquarters in Copenhagen, Denmark. The fund primarily focuses on solving global challenges through investments in key sectors like agribusiness, clean-tech, energy, and healthcare. It has a global reach, with a particular focus on markets in Malaysia, Europe, and the United States. The firm targets early-stage startups and seed-stage companies that are developing innovative solutions with potential for significant impact. 3B Ventures has been involved in notable investments like AnaCardio, a biopharma company focused on medical advancements, where they participated in a substantial $18 million funding round. The fund’s average deal size is around $18 million, indicating that it takes a substantial approach to backing its portfolio companies. Founded by James Digby and Jan-Cayo Fiebig, 3B Ventures is committed to not only providing capital but also delivering strategic support to help companies scale and solve large-scale global problems. The firm tends to look for entrepreneurs passionate about creating change, with business models that align with their vision for a sustainable and impactful future. They prefer to work with founders who have a clear path to growth and profitability, and they actively engage in nurturing these businesses through their extensive network and resources. Entrepreneurs looking to approach 3B Ventures are encouraged to present well-developed solutions with demonstrable traction in key markets.

3CC | Third Culture Capital is a Boston-based venture capital firm that focuses on early-stage investments at the intersection of healthcare, human capital, and financial capital. Founded with a mission to drive diversity, innovation, and equity in healthcare, 3CC invests in startups that bring together cross-cultural and cross-disciplinary approaches to healthcare innovation. The firm’s unique name, "Third Culture," reflects its commitment to supporting entrepreneurs with diverse backgrounds who are poised to disrupt traditional healthcare models. 3CC’s investment strategy targets innovations that can improve patient outcomes, reduce costs, and enhance the overall experience of care for both patients and providers. The firm typically makes investments ranging from $250,000 to $1 million, and prefers to lead funding rounds, providing not just capital but also strategic support through its extensive network of healthcare professionals. 3CC’s portfolio includes companies that are making significant strides in various healthcare sectors, such as Ciba Health, Voiceitt, and Pragma Bio, each focused on leveraging technology to solve critical healthcare challenges. The firm is deeply committed to fostering a more inclusive and innovative healthcare industry by lowering barriers to entry for underrepresented entrepreneurs and promoting collaborative decision-making.

3E Bioventures Capital is a prominent venture capital firm specializing in the life sciences sector, focusing on innovative therapeutic drugs and disruptive med-tech. Founded with a mission encapsulated in their name—Expertise, Efficiency, Execution—3E Bioventures actively invests in global health innovators and TechBio, aiming to disrupt conventional paradigms by integrating biology with technology​​. Notable investments include Aravive, which develops biologic drugs targeting tumor metastasis, and C4 Therapeutics, which pioneers small-molecule drugs that degrade disease-causing proteins. Their portfolio also boasts companies like Cytek, which offers a transformative flow cytometry platform, and Twist Bioscience, known for its advanced DNA synthesis technology​​. Geographically, 3E Bioventures operates with a global perspective, maintaining a strong presence in the US and China. They often participate in early-stage and growth-stage investments, providing significant support in both capital and strategic guidance​​. The firm’s team includes experienced professionals such as Li Jing, Frank Yan, and Linda Liu, who leverage their deep industry knowledge to support portfolio companies effectively. They emphasize a science-driven, entrepreneur-friendly approach, working closely with research institutions and companies to address unmet medical needs​. For startups seeking investment, 3E Bioventures looks for breakthrough innovations in biotech and med-tech, focusing on areas with strong medical needs and the potential for significant impact. They prefer to engage with companies that align with their strategic goals and demonstrate a clear pathway to success​​.

3Lines Venture Capital is a Denver-based venture capital firm that was founded in 2016. The firm primarily focuses on early-stage investments in companies leveraging AI and disruptive software technologies, particularly in sectors related to the Future of Work, enterprise solutions, and industry innovations. The firm's investment strategy involves funding startups that are poised to drive significant technological advancements and market transformations. 3Lines has built a robust portfolio that includes notable companies such as Swimlane, a leader in cybersecurity automation, and Arzooo, an Indian retail technology company. Other investments include Aarna Networks in cloud computing and telecommunications, and Tastry, an AI-driven sensory sciences company based in California. 3Lines Venture Capital is known for its strategic approach, often co-investing with other prominent venture capital firms and leveraging a unique investor engagement model that includes managed funds, co-investments, and venture debt. The firm has successfully closed multiple funding rounds, with their second fund closing at $26 million, surpassing the initial target of $20 million. They plan to launch a $100 million Orbit Fund to further expand their investment capabilities. The leadership team at 3Lines includes seasoned professionals with extensive experience in venture capital, technology, and entrepreneurship. Notable members include Hemant Elhence, Operating Partner, and Anil Gupta, Managing Partner for India, both bringing decades of industry expertise to the firm.

3M Ventures, the corporate venture capital arm of 3M, focuses on investing in early-stage companies that align with 3M's strategic priorities. These priorities include automotive electrification, safety, home improvement, consumer electronics, climate tech, sustainable packaging, industrial automation, and semiconductor and data center technologies. Their investment strategy targets companies with strong intellectual property, demonstrated commercial traction, and robust management teams​. Notable investments by 3M Ventures include GrayMatter Robotics, Moxe Health, and Metalenz, which span across artificial intelligence, healthcare, and 3D technology, respectively. 3M Ventures seeks to not only provide financial investment but also leverage 3M's extensive technological platforms, manufacturing capabilities, and global networks to help scale their partner companies​. 3M is also heavily committed to sustainability. The company has pledged $1 billion to achieve carbon neutrality, reduce water use, and improve water quality by 2030. This initiative includes implementing state-of-the-art water purification technology and developing innovative solutions for renewable energy and emissions reduction​.

3x5 Partners is a Portland, Oregon-based venture capital firm that focuses on investments in companies developing solutions for global health and climate challenges. Founded in 2011 by Tony Arnerich and Nicholas Walrod, the firm has raised over $400 million across multiple funds, including their most recent $100 million Fund III. 3x5 Partners primarily invests in late-stage (Series A/B) ventures within sectors such as biotechnology, medical devices, diagnostics, and clean technology. The firm is known for its commitment to long-term partnerships, often leading early investment rounds and providing significant follow-on funding. Notable investments include companies like Fervo Energy, Arch Oncology, and Smart Wires, all of which align with their mission to create meaningful social and environmental impact. 3x5 Partners differentiates itself by focusing on capital-intensive, high-impact ventures that are often overlooked by traditional venture capital firms. They take an active role in the companies they invest in, serving as board members and strategic partners to guide these ventures through critical growth stages. The firm's leadership team, which includes seasoned investors like Joe Biller and David Yeh, is deeply experienced in both impact investing and venture capital, ensuring that they not only generate strong returns for their investors but also contribute to solving some of the world's most pressing problems.

415 Capital is a Munich-based venture capital firm that specializes in investing in breakthrough medical technologies, particularly those addressing critical unmet needs in cardiovascular and neurovascular diseases. With a focus on improving patient outcomes and reducing healthcare costs, 415 Capital invests in startups across Europe, Israel, and North America, typically writing checks between €5 million and €15 million per company. The firm’s portfolio boasts several cutting-edge companies like Supira Medical, which is developing a percutaneous ventricular assist device for high-risk heart patients, and Distalmotion, known for its innovative surgical robotics platform. 415 Capital avoids biotech, healthcare services, and wellness products, honing in exclusively on medtech innovations. Their strategy emphasizes deep involvement from the R&D stage through commercialization, leveraging close relationships with healthcare providers and access to a €2 billion commercial channel in Europe. The firm’s team combines expertise in investment, medical device commercialization, and clinical practice, ensuring they remain at the forefront of medical innovation. Historically, 415 Capital has been part of significant advancements such as the development of transcatheter heart valves and renal denervation technologies. Their approach to venture capital is deeply rooted in the belief that pioneering medical technologies can simultaneously improve healthcare and generate substantial returns.

4DX Ventures is a prominent venture capital firm dedicated to fostering technological innovation across Africa. Established in 2014, the firm focuses on early to growth-stage investments in diverse sectors, including fintech, e-commerce, healthtech, climate tech, edtech, and logistics. Noteworthy portfolio companies include Andela, Flutterwave, and mPharma, showcasing their commitment to supporting transformative startups on the continent. Geographically, 4DX Ventures has a strong presence in key African markets with offices in Accra, Cairo, and Nairobi. This regional focus allows them to provide robust support and leverage local insights effectively. Their investment strategy is characterized by a deep commitment to partnering with visionary entrepreneurs. They emphasize rigorous due diligence and provide strategic, operational, and technical support to help startups scale. The firm typically leads investment rounds, ensuring substantial backing and ongoing guidance. 4DX Ventures was co-founded by Peter Orth, Walter Baddoo, Daniel Marlo, and Raaid Ahmad, who collectively bring a wealth of experience from prestigious institutions like Morgan Stanley and Bridgewater Associates. The team is dedicated to maintaining high standards of integrity, transparency, and excellence in all their endeavors. Recently, 4DX secured a $10.5 million investment from the International Finance Corporation (IFC) for their third pan-African fund, further solidifying their capacity to drive impactful investments across the continent. Startups are encouraged to approach 4DX with innovative solutions that have the potential for significant impact and scalability.

500 Global, formerly known as 500 Startups, is a prominent venture capital firm with a robust global presence and over $2.4 billion in assets under management. Since its inception in 2010, it has invested in more than 2,800 companies across 80+ countries. Some of its most notable investments include Credit Karma, Twilio, Canva, Grab, Bukalapak, The RealReal, Talkdesk, Udemy, and Ipsy​​. 500 Global's industry focus spans various sectors, with significant investments in consumer services, software-as-a-service (SaaS), fintech, and media​ (Proptech Zone)​. Its geographic focus is truly global, with operations in major innovation hubs such as Silicon Valley, New York, London, Singapore, and Mexico City, as well as emerging markets like Lagos, Jakarta, and Riyadh​​. The fund's strategy involves early-stage investments, providing seed capital along with comprehensive support through its Seed Accelerator Programs. These programs emphasize digital marketing, customer acquisition, lean startup methodologies, and fundraising strategies. 500 Global prefers to invest in companies with high growth potential and innovative business models​. Typically, 500 Global invests an average of $150,000 to $250,000 in initial seed rounds and often leads these rounds. The firm is known for its hands-on approach, leveraging its extensive network of mentors, industry experts, and alumni to support portfolio companies. Recently, 500 Global has been active in launching thematic funds targeting specific industries and regions, further expanding its investment reach​​. The leadership team includes Christine Tsai, the CEO and Founding Partner, who has steered the firm’s growth and global expansion. 500 Global's diverse team of over 100 members spans more than 30 countries, bringing a wealth of experience as entrepreneurs, investors, and operators from leading tech companies​.

5AM Ventures, established in 2002, is a prominent venture capital firm specializing in early-stage investments in life sciences. They have a significant presence in both San Francisco and Boston. The firm focuses on biopharmaceuticals, drug delivery technologies, and life science instruments. Their portfolio includes notable companies like Envoy, Epirus, Flexion, Homology Medicines, and Ideaya Biosciences, showcasing their broad impact across the healthcare sector. 5AM Ventures adopts a hands-on approach through their 4:59 Initiative, partnering with academics and entrepreneurs to incubate breakthrough science. They provide both venture capital for private therapeutic companies and public equity investments in small and mid-cap biotech firms. This strategy allows them to support companies from inception through to later stages of development and public offerings. Geographically, 5AM Ventures focuses on investments within the United States, fostering innovation in healthcare by backing companies that address critical medical needs through cutting-edge technology. Their recent exits include companies like Escient Pharmaceuticals and Impel Neuropharma, demonstrating their successful track record. The team at 5AM Ventures includes co-founders Andrew Schwab and John Diekman, along with managing partner Kush Parmar. Their combined expertise in science, medicine, and finance positions them as key players in shaping the future of life sciences. For startups looking to partner with a venture capital firm that offers deep industry knowledge and a robust network, 5AM Ventures presents a compelling opportunity to advance healthcare innovation.

645 Ventures, founded in 2014 and based in New York City, is an early-stage venture capital firm known for backing high-growth technology startups. The firm has a strong focus on sectors such as SaaS, digital health, e-commerce, and data infrastructure. Their portfolio includes notable companies like FiscalNote, a platform that helps organizations navigate legislation; Iterable, a cross-channel marketing platform; and Goldbelly, a food delivery service that specializes in regional delicacies. 645 Ventures invests in startups that leverage data to enhance customer experiences, transform traditional industries through software, and innovate within the engineering value chain. They are particularly interested in the second wave of SaaS applications, which address the evolving needs of distributed workforces and the adoption of technology in new business areas. The firm is co-founded by Nnamdi Okike and Aaron Holiday, who bring extensive experience and a hands-on approach to supporting their portfolio companies. This includes helping with customer acquisition, talent recruitment, and fundraising strategy. With a geographic focus primarily in the United States, 645 Ventures also maintains a presence in San Francisco to tap into the West Coast's innovation ecosystem. Their investments range from seed to Series B stages, and they actively lead rounds and provide follow-on funding.

6th Man Ventures (6MV) is a dynamic venture capital firm based in New York, specializing in early-stage investments within the web3 ecosystem. With a strong focus on crypto, tech infrastructure, and new economic models for media, entertainment, art, and games, 6MV is dedicated to supporting transformative projects in these sectors. Their investment portfolio includes notable companies like Magic Eden, io.net, and Livepeer. Founded in 2021 by Mike Dudas and Serge Kassardjian, the firm has quickly made a name for itself by investing in projects that push the boundaries of web3 technology. They are particularly interested in startups that demonstrate domain expertise, solve significant problems in large markets, and have a strong ability to execute and scale. 6th Man Ventures typically invests up to $5 million in pre-seed, seed, and Series A rounds, and their approach is hands-on, offering substantial added value through startup operations, marketing, communications, partnership introductions, and product iteration. They seek founders who are building web3-first projects with the potential for massive impact. The team at 6MV is composed of seasoned founders and operators who have deep empathy for the challenges startups face, providing strategic guidance and support to help them succeed. For startups looking to partner with 6MV, the firm prefers concise, clear pitches that highlight the project's unique insights and market potential.

75 & Sunny is a Los Angeles-based venture capital firm and startup studio founded by Spencer Rascoff, the former CEO of Zillow. The firm incubates and invests in startups that provide innovative solutions to everyday problems. Through 75 & Sunny Labs, the firm helps founders from the idea stage onward, offering pre-seed capital, product strategy, hiring support, and access to a network of over 200 venture funds​. The portfolio of 75 & Sunny includes a mix of emerging tech companies such as Pacaso, Recon Food, Queue, and heyLibby, many of which have gone on to raise significant capital from top VCs like Greycroft and Softbank​. Their investment approach is hands-on, providing guidance on fundraising, go-to-market strategies, and operations. The firm particularly focuses on sectors such as real estate, fintech, AI, and consumer tech. Spencer Rascoff leads the firm with a wealth of experience, having co-founded Zillow, Hotwire, and several other successful ventures. The team at 75 & Sunny includes industry veterans like Wil Chockley, who focuses on product and fundraising strategies, and Katie Curnutte, who leads communications.

7percent Ventures is a London-based venture capital firm founded in 2014 by ex-founders Andrew Scott and Andrew Gault. Specializing in early-stage investments, the firm focuses on deep-tech startups with transformative potential, often referred to as "moonshot" companies. 7percent Ventures targets industries such as AI, quantum computing, AR/VR, spacetech, and future computing. Their investment philosophy is driven by supporting highly ambitious projects that aim to disrupt entire industries. The firm typically invests at pre-seed, seed, and Series A stages, with a typical investment range of €100,000 to €1.5 million. Notable companies in their portfolio include Oculus VR, which was acquired by Meta, and Universal Quantum, a pioneer in quantum computing. They also have a strong transatlantic reach, with investments spanning both the U.K. and the U.S., particularly in Silicon Valley. 7percent Ventures’ partners bring over 150 years of combined experience as entrepreneurs and investors, offering not just capital but also strategic mentorship, leveraging their extensive networks to help startups scale. The firm emphasizes the importance of transformative innovation and risk-taking in achieving sector-defining success​.

7wireVentures, co-founded by Glen Tullman and Lee Shapiro, is a venture capital firm that invests in early-stage digital health companies. The firm focuses on empowering consumers with innovative health solutions and technologies. Notable investments from 7wireVentures include Livongo, a chronic care management company that was acquired by Teladoc in a significant $18.5 billion deal, and NOCD, which focuses on providing virtual therapy for obsessive-compulsive disorder. Other prominent portfolio companies include FOLX Health, which offers virtual healthcare for the LGBTQIA+ community, and Brightline, a tech-enabled behavioral health platform for children and families. Recently, 7wireVentures closed a $217 million Growth & Opportunity Fund to support their existing portfolio and invest in Series B and C companies. This new fund brings their total assets under management to over $500 million. The firm continues to focus on "consumer-first, tech-enabled health and care solutions," reflecting their commitment to driving the digital transformation of healthcare.

8-Bit Capital is a venture capital firm based in San Francisco, co-founded by Jonathan Abrams and Kent Lindstrom. The firm specializes in early-stage investments, particularly in software startups that focus on AI, cloud computing, cybersecurity, enterprise solutions, fintech, and social networking platforms. Their mission is to back companies that are building innovative tools and platforms to connect people and businesses in new and impactful ways. 8-Bit Capital invests primarily at the pre-seed and seed stages, aiming to support entrepreneurs with the potential to drive significant change in their industries. The team at 8-Bit Capital leverages their extensive experience as entrepreneurs and investors to provide not just funding, but also strategic guidance and access to a robust network of industry contacts. Some of their notable investments include companies like 1up, which develops AI-powered sales tools, and Bytewax, a leader in stream processing. The firm is known for its focus on transformative technologies and its commitment to helping founders navigate the complex challenges of scaling early-stage startups. If you're a startup in these fields, 8-Bit Capital offers a compelling combination of financial support and deep industry expertise to help you grow.

83North is a global venture capital firm with over $2.2 billion in assets under management. Founded in 2006, the firm invests across various stages and sectors, with a focus on supporting exceptional entrepreneurs in building global category-leading companies. The firm operates with a philosophy that emphasizes deep involvement with portfolio companies, long-term relationships, and a lean operational structure, maintained by its four equal partners: Laurel Bowden, Gil Goren, Yoram Snir, and Arnon Dinur. 83North has a significant presence in the US, Europe, and Israel, investing in industries ranging from software and IT to fintech, healthcare, and consumer technology. Notable investments include companies such as Mirakl, Payoneer, Paddle, and Snappy. The firm prides itself on having helped create 14 unicorns and achieving 32 successful exits out of nearly 90 investments. Their investment strategy is grounded in the belief that venture capital is not a scalable business, but rather one that benefits from a focused, hands-on approach. This strategy allows 83North to maintain quick, transparent processes and build a high level of trust with their entrepreneurs.

8VC is a dynamic venture capital firm that focuses on investing in cutting-edge technology and life sciences startups. Notable investments in their portfolio include industry leaders such as Flexport, Guardant Health, Joby Aviation, and Palantir. 8VC primarily targets sectors like healthcare, logistics, IT infrastructure, and defense, with a strong emphasis on transformative technologies that drive significant societal impact. Geographically, 8VC invests globally but has a particular focus on the United States. The firm's investment strategy is centered on early-stage companies, often leading funding rounds with check sizes ranging from $100K to $50M. 8VC is known for its hands-on approach, supporting entrepreneurs not just with capital, but also with deep operational expertise and a robust network. They actively participate in the development of their portfolio companies, sometimes even building companies from the ground up when necessary. Led by Joe Lonsdale, a co-founder of Palantir, 8VC's team includes seasoned professionals with diverse backgrounds in technology, finance, and entrepreneurship. The team operates out of multiple locations, including San Francisco and Austin, positioning them at the heart of the innovation ecosystem. Startups looking to engage with 8VC should be prepared to demonstrate a strong potential for societal impact and innovative technology solutions. The firm values direct, compelling pitches and prefers to be approached through warm introductions within their extensive network.

9Yards Capital is a San Francisco-based global investment firm focused on growth-stage technology companies, particularly in fintech and logistics. With a strategic emphasis on companies that leverage technology to transform foundational industries, the firm aims to be more than just financial backers. They provide deep industry expertise, particularly in regulatory frameworks, which allows them to offer unique value to their portfolio companies. This includes high-profile investments like Robinhood, Coinbase, Better, and Toast, among others. 9Yards operates across both the U.S. and Europe, targeting investments from early-stage ventures to Series B+ rounds. They typically invest between $100,000 to $10 million, depending on the company's stage and needs. Known for its patient, long-term approach, the firm ensures that its portfolio companies have the resources and connections needed to scale efficiently, often co-investing with other major players in the venture capital landscape. The leadership at 9Yards includes prominent figures such as David Fisher and George Osborne, who bring strong financial and operational expertise. Their team also benefits from the guidance of strategic advisers like Malcolm Turnbull and Admiral Mike Rogers, adding a diverse and influential network that strengthens their ability to impact industries globally. With over $800 million in assets under management, 9Yards Capital continues to be a significant player in shaping the future of technology-driven industries

A.Capital Ventures, co-founded by Ronny Conway and Ramu Arunachalam, focuses on providing strategic investments and support to early-stage startups. Based in the US, A.Capital is noted for its flexible investment approach, allowing startups to grow without significant dilution or stringent ownership thresholds. They prioritize high-potential sectors like AI, blockchain, and enterprise software. A.Capital's portfolio includes notable companies like Notion, Airbnb, and Coinbase, showcasing their strength in backing transformative technologies. The firm offers more than just capital; they provide valuable connections, world-class advice, and access to top talent, thanks to their partners' extensive experience at Google and other tech giants. A.Capital avoids traditional board seat requirements, instead fostering a collaborative partnership with founders. This unique model has enabled startups to scale effectively, leveraging the firm's resources and networks without compromising control. Entrepreneurs can approach A.Capital through their network of referrals or by directly engaging with their team during industry events. With a clear focus on building the future through innovation and a hands-on investment strategy, A.Capital Ventures stands out as a pivotal supporter of groundbreaking startups across various tech-driven industries​.

A Partners Capital is a global outsourced CIO (Chief Investment Officer) firm that provides tailored investment solutions to endowments, foundations, private clients, and institutions. Established in 2001, the firm is headquartered in London with additional offices in Boston, San Francisco, Singapore, Paris, and Hong Kong​. A Partners Capital focuses on alternative investments, including private equity, real estate, and hedge funds, seeking to deliver superior long-term returns through a rigorous, research-driven approach. Their investment philosophy emphasizes diversification, sustainability, and long-term value creation, utilizing their extensive global network and deep industry expertise. The firm provides clients with bespoke investment strategies that are aligned with their financial objectives and risk tolerance. A Partners Capital also manages private market mandates, offering opportunities in co-investments and direct investments across multiple sectors​. With a commitment to transparency and strong governance, A Partners Capital builds enduring partnerships with clients, helping them navigate complex market environments while maximizing returns.

A-Star is a dynamic investment firm that excels in scaling early-stage companies with significant growth potential. The firm’s strategy revolves around providing both capital and strategic support, ensuring that startups can transition from promising ideas to thriving businesses. A-Star is deeply committed to fostering long-term partnerships, taking a hands-on approach in guiding companies through critical growth stages. The firm’s team boasts a wealth of experience in entrepreneurship, finance, and venture capital, enabling them to identify and nurture innovative businesses across a wide range of sectors. This expertise allows A-Star to build a diverse portfolio of transformative companies, each poised to make a substantial impact in their respective industries. With a keen focus on sustainable growth and long-term success, A-Star partners with entrepreneurs who share a vision for innovation and excellence. Through their dedicated involvement, A-Star helps these companies navigate the complexities of scaling, providing the necessary tools and resources to achieve market leadership. The firm’s approach is characterized by its emphasis on collaboration and its commitment to the sustained success of its portfolio companies. By leveraging their extensive network and industry insights, A-Star not only supports the growth of individual companies but also contributes to the broader entrepreneurial ecosystem. Their mission is to empower visionary founders and turn high-potential startups into market-leading enterprises, driving meaningful change and creating lasting value.