Lewis & Clark Ventures

Lewis & Clark Ventures is an early-stage venture capital firm based in St. Louis, Missouri, specializing in B2B software investments. Founded by former founders and operators, the firm leverages its team's extensive entrepreneurial experience to partner with dynamic founders aiming to build successful companies. They focus on late seed to Series A investments, typically ranging from $2 million to $3 million per initial investment. The firm's portfolio includes innovative companies like Beam Benefits, Benson Hill, and GreenLight Biosciences. Lewis & Clark Ventures is known for its hands-on approach, often taking board seats and providing strategic, technical, and commercial support to help their portfolio companies scale effectively. Their investment strategy targets high-growth opportunities in overlooked geographies, emphasizing the importance of founder vision, team strength, and market potential. The firm values transparency, smart growth, and long-term partnerships, aiming to support founders not just with capital but also with mentorship and access to their extensive networks.