TL Ventures

TL Ventures is a long-established venture capital firm headquartered in Wayne, Pennsylvania, founded in 1988 and historically part of the Safeguard Scientifics family of early-stage venture funds. Over its history it has raised seven funds and manages more than $1.5 billion in assets, making over 240 investments. The firm focuses on software, information technology, enterprise applications, business services and life sciences, including biotech and drug discovery, typically backing Series A and Series B companies and following into Series C with cheques generally in the $1 to 10 million range, and it is willing to lead. Its track record includes 84 active companies and 77 exits, with one unicorn, four IPOs and 38 acquisitions; flagship outcomes include iSpot.tv, the TV advertising-measurement company that became a unicorn in 2022 roughly eight years after TL first invested, Esperion Therapeutics, which listed on NASDAQ in 2013, and Pac-West Telecomm. TL Ventures was co-founded by Robert E. Keith, Jr., who has served as Managing Director and CEO of the management companies since inception, and Ira Mark Lubert, a co-founder through the late 1990s who later built Independence Capital Partners and Lubert-Adler; Mark J. DeNino serves as a Managing Director alongside partners including Gary J. Anderson and Carolyn C. Harkins. Beyond its own funds, TL partners helped launch firms such as EnerTech Capital, Hamilton Lane, Internet Capital Group, Peak 6 and Penn Mezzanine. The firm maintains offices in Philadelphia, Austin, Dallas and Los Angeles, sustaining a multi-decade track record across software and life sciences.